Epilepsy monotherapy Adult & childn >12 yr Initially 25 mg once daily for 2 wk followed by 50 mg once daily for 2 wk. May be increased by a max of 50-100 mg every 1-2 wk to usual maintenance dose of 100-200 mg given in 2 divided doses.
Add-on therapy (w/o valproate) Adult 50 mg once daily for 2 wk followed by 50 mg bid for 2 wk. May be increased by a max of 100 mg every 1-2 wk to usual maintenance dose of 200-400 mg daily in 2 divided doses.
Childn 2-12 yr Initially 600 mcg/kg daily in 2 divided dosed for 2 wk followed by 1.2 mg/kg in 2 divided doses for 2 wk. May be increased by a max of 1.2 mg/kg every 1-2 wk to usual maintenance dose of 5-15 mg/kg in 2 divided doses.
Add-on therapy (w/ valproate) Adult Initially 25 mg every other day for 2 wk followed by 25 mg once daily for 2 wk. May be increased by a max of 25-50 mg every 1-2 wk to usual maintenance dose of 100-200 mg daily as a single dose or in 2 divided doses.
Childn Initially 150 mcg/kg once daily for 2 wk followed by 300 mcg/kg once daily for 2 wk. May be increased by a max of 300 mcg/kg every 1-2 wk to usual maintenance dose of 1-5 mg/kg once daily or in 2 divided doses.
Bipolar disorder monotherapy Initially 25 mg once daily, gradually increased to 200 mg daily over 6 wk.
Patient taking valproate 25 mg every other day & target dosage of 100 mg/day from wk 6.
Patient w/ carbamazepine or other enzyme inducing drugs Initially 50 mg once daily, gradually increased up to 400 mg/day from wk 7. Dosages >50 mg/day can be given once daily or as 2 divided doses.
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